

Welcome to PONTIAC II
PONTIAC-II is an investigator initiated trial, organized by opinion
leaders in the field of heart failure, diabetes and biomarkers. Unlike
most trials of diabetes, PONTIAC-II is a primary prevention trial. It
will test the hypothesis that a biomarker-based approach will identify
people with diabetes who benefit from treatment with ACE-inhibitors and
beta-blockers to prevent the development of cardiovascular disease.
PONTIAC-I provides a strong rationale for this aim. Based on the results
of PONTIAC-I the Guidelines of the ESC, ACC and AHA have suggested that
NT-proBNP may be used to select patients with diabetes for intensive
work-up/treatment to delay or prevent progression to heart failure.
PONTIAC II hopes to confirm this hypothesis. If you would like to
participate and believe your centre could enrol a substantial number of
participants, please get in touch.